GLP-1 medications are the most effective weight-loss tools we have, and also among the most confusing to price. Brand-name list prices are high, insurance coverage for weight loss is inconsistent, and compounded options exist in a landscape that shifts with regulation. Here is an honest framework for thinking about cost.
Brand-name pricing
Brand-name semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) carry high monthly list prices without insurance, often well over a thousand dollars a month at retail. Manufacturer savings programs can reduce that for some commercially insured patients, but eligibility is narrow and frequently excludes weight-loss indications. The result is that many people who would benefit cannot access the brand versions affordably.
Insurance coverage is the wild card
Coverage for GLP-1s is far better for type 2 diabetes than for weight management. Many plans cover the diabetes indications and exclude obesity, or require step therapy and prior authorization. Whether you have coverage, and for which indication, is the single biggest factor in what you actually pay. It is worth checking your specific plan's formulary before assuming anything.
Compounded GLP-1s
Compounded semaglutide and tirzepatide, prescribed when clinically appropriate, are typically billed by the pharmacy at cost and are usually the more affordable route. As a rule of thumb, compounded semaglutide runs less per month than compounded tirzepatide, because tirzepatide is the newer, more complex molecule. Compounding availability tracks FDA shortage status and regulation, so it can change, a responsible prescriber tells you when it does. We cover the details on the compounded GLP-1 explainer.
The mistake to avoid
Do not let price alone pick your drug. If two options would both work for you and budget is tight, semaglutide is usually the more affordable path. But a cheaper drug that does not fit your physiology is not a deal, and the most expensive outcome is paying for months of a medication while an untreated thyroid or insulin problem blunts your results. Cost is one input, not the whole decision. For how the two molecules actually compare, see tirzepatide vs semaglutide.
What you get with KAYU
KAYU prices the medical care transparently, and compounded GLP-1 is billed by the pharmacy at cost rather than marked up. Every protocol starts with the metabolic labs that determine whether a GLP-1 is even the right first move, because the worst value is money spent on the wrong intervention. See the full program on our GLP-1 page and the clinical picture on our weight management page.
Take the 2-minute KAYU assessment for a transparent read on what your protocol would actually cost.
This article is educational and does not substitute for a provider-patient relationship. Pricing varies by pharmacy, dose, coverage, and regulation. Individual results vary.