The science behind your protocol.
Mechanism-of-action explainers, clinical evidence reviews, and protocol guides - written for the informed patient, reviewed by KAYU providers.
GLP-1 Receptor Agonists: Mechanism of Action
Semaglutide and tirzepatide are reshaping metabolic medicine. GLP-1 receptor agonists reduce appetite via hypothalamic signaling, enhance insulin secretion through incretin pathways, slow gastric emptying, and demonstrate cardiovascular and neuroprotective benefits. This review covers receptor pharmacology, clinical trial data (STEP, SURMOUNT), and emerging off-label applications.
Semaglutide: How It Works, Dosing, and What to Expect
A single-receptor GLP-1 agonist behind Ozempic and Wegovy. How semaglutide reduces appetite, the standard titration schedule, side effects, and the compounded-vs-brand question.
Tirzepatide: Dual-Receptor Mechanism, Dosing, and Results
The dual GIP and GLP-1 agonist behind Mounjaro and Zepbound. Why two receptors produce more weight loss, the full titration chart, side effects, and compounded vs brand.
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