The science behind your protocol.
Mechanism-of-action explainers, clinical evidence reviews, and protocol guides — written for the informed patient, reviewed by KAYU providers.
Growth Hormone Secretagogues: CJC-1295 + Ipamorelin
CJC-1295 (a GHRH analog) and Ipamorelin (a selective ghrelin receptor agonist) work synergistically to produce pulsatile growth hormone release that mimics physiological patterns. Unlike exogenous GH, this combination preserves the hypothalamic-pituitary feedback loop. We cover GHRH receptor binding, GH pulse dynamics, IGF-1 response, and safety data.
GLP-1 Receptor Agonists: Mechanism of Action
Semaglutide and tirzepatide are reshaping metabolic medicine. GLP-1 receptor agonists reduce appetite via hypothalamic signaling, enhance insulin secretion through incretin pathways, slow gastric emptying, and demonstrate cardiovascular and neuroprotective benefits. This review covers receptor pharmacology, clinical trial data (STEP, SURMOUNT), and emerging off-label applications.
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Two minutes to the assessment. One week to your first consult. A protocol built on your bloodwork from a provider who knows your name.